Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells

Chih Wen Shu, Jing Ru Weng, Hsueh Wei Chang, Pei Feng Liu, Jih Jung Chen, Chien Chi Peng, Jia Wen Huang, Wei Yu Lin, Ching Yu Yen

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy-related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. In this study, we found that the extracted Tribulus terrestris fruit (TT-(fr)) and Xanthium strumarium fruit had inhibitory effects on autophagy inhibition in both SAS and TW2.6 oral cancer cells. Moreover, the fruit extracts had differential effects on cell proliferation of oral cancer cells. In addition, the fruit extracts hampered cell migration and invasion of oral cancer cells, particularly in TT-(fr) extracts. Our results indicated that TT-(fr) extracts consistently inhibited autophagic flux, cell growth and metastatic characteristics of oral cancer cells, suggesting TT-(fr) might contain function ingredient to suppress oral cancer cells.
原文英語
頁(從 - 到)1173-1180
頁數8
期刊Environmental Toxicology
36
發行號6
DOIs
出版狀態已發佈 - 6月 2021

ASJC Scopus subject areas

  • 毒理學
  • 管理、監督、政策法律
  • 健康、毒理學和誘變

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