Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy

Giimel Ajnai, Amy Chiu, Tzuchun Kan, Chun Chia Cheng, Teh Hua Tsai, Jungshan Chang

研究成果: 雜誌貢獻文章同行評審

111 引文 斯高帕斯(Scopus)

摘要

Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and tissue barriers into tumor foci, which indicates gold nanoparticles as a more effective drug carrier with great merits in reducing cytotoxicity and economic burden in patients. Moreover, gold nanoparticles display several unique characterizations with multiple functions in therapeutics, imaging, and surface modification, suggesting gold nanoparticles may become effective antitumor drug carriers. In this review article, we discuss the limitations and applications of gold nanoparticles in surface modification, targeting strategy, and safety considerations.

原文英語
頁(從 - 到)172-178
頁數7
期刊Journal of Experimental and Clinical Medicine(Taiwan)
6
發行號6
DOIs
出版狀態已發佈 - 12月 1 2014

ASJC Scopus subject areas

  • 醫藥 (全部)

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