Treatment of neutropenia with intravenous immunoglobulin in autoimmune neutropenia of childhood

S. H. Chen, D. C. Liang, H. C. Liu, M. Lin

研究成果: 雜誌貢獻文章同行評審

摘要

Five patients (2 boys, 3 girls) with autoimmune neutropenia (AIN) which developed mainly in infancy were treated with intravenous immunoglobulin (IVIG) and followed up for 69-95 months. AIN was proved by positive antineutrophil antibodies detected by a granulocyte agglutination test. Of these five patients, three patients experienced septicemia prior to treatment. These patients also had several episodes of upper respiratory tract infection, acute otitis media, skin infection and enterocolitis. Basically, IVIG 2 g/kg was given intravenously for each course of treatment. The neutrophil counts increased significantly in all patients with the initial IVIG therapy and two patients went into remission. Subsequent infusions also caused neutrophil counts to increase. Although many patients with AIN have a benign course, those who have significant infections could be treated, acutely or preventively, with IVIG.

原文英語
頁(從 - 到)347-353
頁數7
期刊International Journal of Pediatric Hematology/Oncology
6
發行號5
出版狀態已發佈 - 2000
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 血液學
  • 兒科、圍產兒和兒童健康

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