Treatment of cosmetic tattoos using carbon dioxide ablative fractional resurfacing in an animal model: A novel method confirmed histopathologically

Chia Chen Wang, Chuen Lin Huang, Yuh Mou Sue, Shao Chen Lee, Fur Jiang Leu

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Background Treating cosmetic tattoos using quality-switched lasers is difficult. Objective We used carbon dioxide ablative fractional resurfacing (CO2 AFR) to remove cosmetic tattoos and examined the pathophysiologic mechanisms involved in this technique in an animal model. Methods and Materials Twelve rats were tattooed on their backs with white and flesh-colored pigments. Half of each tattoo was treated with CO2 AFR (5 sessions at 1-month intervals), and the other half was the untreated control. An independent observer reviewed photographic documentation of clinical response. Serial skin samples obtained at baseline and at various times after laser treatment were evaluated using histologic and immunohistochemical methods. Results Four rats had excellent responses to laser treatment and eight had good responses. White and flesh-colored tattoos had similar clearance rates and tissue reactions. Histologic analysis showed immediate ablation of tattoo pigments in the microscopic ablation zones. Tattoo pigments in the microscopic coagulation zones migrated to the epidermis and became part of the microscopic exudative necrotic debris appearing on day 2 that was exfoliated after 5 days. Increased fibronectin expression around the microscopic treatment zones during the extrusion of tattoo pigments indicated that wound healing facilitates this action. Conclusion CO2 AFR successfully removes cosmetic tattoos.

原文英語
頁(從 - 到)571-577
頁數7
期刊Dermatologic Surgery
39
發行號4
DOIs
出版狀態已發佈 - 四月 2013

ASJC Scopus subject areas

  • Dermatology
  • Surgery

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