Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration

Yung-Hsiao Chiang, C. V. Borlongan, F. C. Zhou, B. J. Hoffer, Yun Wang

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Various trophic factors in the transforming growth factor-β (TGF-β) superfamily have been reported to have neuroprotective and neuroregenerative effects. Intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or bone morphogenetic proteins (BMPs), both members of the TGF-β family, reduce ischemia- or 6-hydroxydopamine (6-OHDA)-induced injury in adult rat brain. Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species. In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models.
原文英語
頁(從 - 到)1-9
頁數9
期刊Cell Transplantation
14
發行號1
出版狀態已發佈 - 2005
對外發佈

ASJC Scopus subject areas

  • 細胞生物學
  • 移植

指紋

深入研究「Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration」主題。共同形成了獨特的指紋。

引用此