Translocation t(11;22) in esthesioneuroblastoma

Jacqueline Whang-Peng, Carl E. Freter, Turid Knutsen, J. J. Nanfro, Adi Gazdar

研究成果: 雜誌貢獻文章同行評審

69 引文 斯高帕斯(Scopus)

摘要

Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
原文英語
頁(從 - 到)155-157
頁數3
期刊Cancer Genetics and Cytogenetics
29
發行號1
DOIs
出版狀態已發佈 - 一月 1 1987
對外發佈Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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