Translocation of c-sis protooncogene in peripheral neuroepithelioma

Carol J. Thiele, Jacqueline Whang-Peng, Chien Song Kao-Shan, James Miser, Mark A. Israel

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Molecular genetic analysis of the c-sis protooncogene was performed on two neuroepithelioma cell lines carrying a t(11;22)(q24;q12). The c-sis protooncogene was found by in situ hybridization to be translocated from its germline position on chromosome #22 to the derivative chromosome #11 in each cell line. However, it was not rearranged or amplified in either cell line examined. In addition, we did not detect c-sis transcripts in Northern blots of poly (A)+ RNA. This is similar to results found in Ewing's sarcoma, which carries a cytogenetically indistinguishable translocation from neuroepithelioma.
原文英語
頁(從 - 到)119-128
頁數10
期刊Cancer Genetics and Cytogenetics
24
發行號1
DOIs
出版狀態已發佈 - 一月 1 1987
對外發佈

ASJC Scopus subject areas

  • 分子生物學
  • 遺傳學
  • 癌症研究

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