Translocation between chromosome 5q35 and chromosome 11q13 - An unusual cytogenetic finding in a primary refractory acute myeloid leukemia

T. F. Wang, S. W. Horsley, K. F. Lee, S. C. Chu, C. C. Li, R. H. Kao

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Cytogenetic abnormalities are observed in approximately two-thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B-cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case.
原文英語
頁(從 - 到)160-163
頁數4
期刊Clinical and Laboratory Haematology
28
發行號3
DOIs
出版狀態已發佈 - 六月 1 2006
對外發佈Yes

指紋

Chromosomes
Acute Myeloid Leukemia
Cytogenetics
Refractory materials
Genes
Idarubicin
Chemotherapy
Flow cytometry
Cytarabine
Bone
Induction Chemotherapy
Fluorescence
Cells
Fluorescence In Situ Hybridization
Chromosome Aberrations
Flow Cytometry
B-Lymphocytes
Bone Marrow

ASJC Scopus subject areas

  • Hematology

引用此文

Translocation between chromosome 5q35 and chromosome 11q13 - An unusual cytogenetic finding in a primary refractory acute myeloid leukemia. / Wang, T. F.; Horsley, S. W.; Lee, K. F.; Chu, S. C.; Li, C. C.; Kao, R. H.

於: Clinical and Laboratory Haematology, 卷 28, 編號 3, 01.06.2006, p. 160-163.

研究成果: 雜誌貢獻文章

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abstract = "Cytogenetic abnormalities are observed in approximately two-thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B-cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case.",
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TY - JOUR

T1 - Translocation between chromosome 5q35 and chromosome 11q13 - An unusual cytogenetic finding in a primary refractory acute myeloid leukemia

AU - Wang, T. F.

AU - Horsley, S. W.

AU - Lee, K. F.

AU - Chu, S. C.

AU - Li, C. C.

AU - Kao, R. H.

PY - 2006/6/1

Y1 - 2006/6/1

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AB - Cytogenetic abnormalities are observed in approximately two-thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B-cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case.

KW - Acute myeloid leukemia

KW - Chromosome 11

KW - Chromosome 5

KW - Translocation

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