Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

Chi Mei Wang, Shan Jen Li, Chi Hao Wu, Chien Ming Hu, Hui Wen Cheng, Jung Su Chang

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

原文英語
頁(從 - 到)605-610
頁數6
期刊Asian Pacific Journal of Cancer Prevention
15
發行號2
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

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