摘要

Blood and blood-component therapy triggers immunological reactions in recipients. Transfusion-related immunomodulation [TRIM] is an important complex biological immune reaction to transfusion culminating in immunosuppression. The mechanisms underlying TRIM include the presence of residual leukocytes and apoptotic cells, the transfusion of immunosuppressive cytokines either present in donor components or generated during blood processing, the transfer of metabolically active growth factor-loaded microparticles and extracellular vesicles and the presence of free hemoglobin or extracellular vesicle-bound hemoglobin. TRIM variables include donor-specific factors as well as processing variables. TRIM may explain, at least in part, the controversial negative clinical outcomes observed in cancer patients receiving transfusion in the context of curative-intent surgeries. The use of novel technologies including metabolomics and proteomics on stored blood may pave the way for a deeper understanding of TRIM in general and its impact on cancer progression.
原文英語
頁(從 - 到)336-340
頁數5
期刊Transfusion and Apheresis Science
56
發行號3
DOIs
出版狀態已發佈 - 六月 1 2017

指紋

Immunomodulation
Neoplasms
Hemoglobins
Tissue Donors
Metabolomics
Immunosuppressive Agents
Antigen-Antibody Complex
Proteomics
Immunosuppression
Intercellular Signaling Peptides and Proteins
Leukocytes
Cytokines
Technology

ASJC Scopus subject areas

  • Hematology

引用此文

Transfusion-related immunomodulation and cancer. / Goubran, Hadi; Sheridan, David; Radosevic, Julia; Burnouf, Thierry; Seghatchian, Jerard.

於: Transfusion and Apheresis Science, 卷 56, 編號 3, 01.06.2017, p. 336-340.

研究成果: 雜誌貢獻回顧型文獻

Goubran, H, Sheridan, D, Radosevic, J, Burnouf, T & Seghatchian, J 2017, 'Transfusion-related immunomodulation and cancer', Transfusion and Apheresis Science, 卷 56, 編號 3, 頁 336-340. https://doi.org/10.1016/j.transci.2017.05.019
Goubran, Hadi ; Sheridan, David ; Radosevic, Julia ; Burnouf, Thierry ; Seghatchian, Jerard. / Transfusion-related immunomodulation and cancer. 於: Transfusion and Apheresis Science. 2017 ; 卷 56, 編號 3. 頁 336-340.
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