Transcriptome analysis and prognosis of ALDH isoforms in human cancer

Peter Mu Hsin Chang, Che Hong Chen, Chi Chun Yeh, Hsueh Ju Lu, Tze Tze Liu, Ming Huang Chen, Chun Yu Liu, Alexander T.H. Wu, Muh Hwa Yang, Shyh Kuan Tai, Daria Mochly-Rosen, Chi Ying F. Huang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Overexpression of ALDH is associated with cancer stem-like features and poor cancer prognosis. High ALDH activity has been observed in cancer stem-like cells. There are a total of 19 human ALDH isoforms, all of which are associated with reducing oxidative stress and protecting cells from damage. However, it is unknown whether all ALDHs are associated with poor cancer prognosis and which ones play a significant role in cancer progression. In this study, we used RNA sequencing data from The Cancer Genome Atlas (TCGA) to evaluate the differential expression of 19 ALDH isoforms in 5 common human cancers. The 19 ALDH genes were analyzed with an integrating meta-analysis of cancer prognosis. Genotyping and next-generation RNA sequencing for 30 pairwise samples of head and neck squamous cell carcinoma were performed and compared with the TCGA cohort. The analysis showed that each ALDH isoform had a specific differential expression pattern, most of which were related to prognosis in human cancer. A lower expression of ALDH2 in the tumor was observed, which was independent from the ALDH2 rs671 SNP variant and the expression of other mitochondria-associated protein coding genes. This study provides new insight into the association between ALDH expression and cancer prognosis.

原文英語
頁數1
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 二月 9 2018

ASJC Scopus subject areas

  • General

指紋 深入研究「Transcriptome analysis and prognosis of ALDH isoforms in human cancer」主題。共同形成了獨特的指紋。

引用此