@article{5db1265a8d5d4b0c940971e91ade128e,
title = "Transcription factor SPZ1 promotes TWIST-mediated epithelial-mesenchymal transition and oncogenesis in human liver cancer",
abstract = "The epithelial-mesenchymal transition (EMT) is an important process in the progression of cancer. However, its occurrence and mechanism of regulation are not fully understood. We propose a regulatory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT through its transactivating ability in increasing TWIST1 expression. We compared the expression of SPZ1 and TWIST1 in specimens of hepatocarcinoma cells (HCCs) and non-HCCs. Expression of SPZ1 exhibited a tumor-specific expression pattern and a high correlation with patients' survival time, tumor size, tumor number and progression stage. Moreover, forced expression and knockdown of SPZ1 in hepatoma cells showed that SPZ1 was able to regulate the cellular proliferation, invasion, and tumorigenic activity in a TWIST1-dependent manner in vitro and in vivo. These data demonstrate that SPZ1, a newly dscribed molecule, transactivates TWIST1 promoters, and that this SPZ1-TWIST axis mediates EMT signaling and exerts significant regulatory effects on tumor oncogenesis.",
author = "Wang, {L. T.} and Chiou, {S. S.} and Chai, {C. Y.} and E. Hsi and Chiang, {C. M.} and Huang, {S. K.} and Wang, {S. N.} and Yokoyama, {K. K.} and Hsu, {S. H.}",
note = "Funding Information: We acknowledge supports from the Liver Disease Prevention and Treatment Research Foundation in Taiwan. This work was supported in part by research grants KMUH 104-4R34 and KMUH 105-5R28, 105-5T10 from Kaohsiung Medical University Hospital, NSC-102-2320-B-037-032-MY3, MOST 105-2314-B-037-070-MY2 from the National Science Council, Taiwan, MOST-104-2314-B-037-043; MOST 104-2320-B-037-033-My2, MOST 104-2314-B-033-002, and MOST-105-2314-B-037-049 from Ministry of Science and Technology, the National Health Research Institutes (NHRI-Ex102-10109B1; NHRI-Ex104-10416S1), Kaohsiung Medical University grant (KMU-TP103G00, G01, G03, G04, G05, KMU-TP103A104, KMU-DT103001, KMUTP104A04, KMU-TPE23, KMU-DT104001, KMU-TP105PR4, and KMU-TP105E00), NIH (CA103867), CPRIT (RP110471 and RP140367) and Welch Foundation (I-1805). Publisher Copyright: {\textcopyright} The Author(s) 2017.",
year = "2017",
month = aug,
day = "1",
doi = "10.1038/onc.2017.69",
language = "English",
volume = "36",
pages = "4405--4414",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "31",
}
