摘要

Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal. Analysis results revealed that among the biochemical parameters, only the glucose concentration was significantly higher in current smokers than in non-smokers; the other parameters showed no significant difference. The concentration of Zn in the PE was significantly lower in all smokers (10 former and 12 current smokers) than in non-smokers, but the other elements did not differ significantly between the two groups and smoker subgroups. Simultaneously, Zn correlated negatively with glucose concentrations in all smokers, positively with lactate dehydrogenase (LDH) concentration in current smoker, and positively with total protein (TP) concentrations in non-smokers. This is for the first time the relation between Zn and certain biochemical parameters in PE was found, the observation requiring further studies to explain the potential interactions between this element and glucose, LDH, and TP concentrations.
原文英語
頁(從 - 到)14-20
頁數7
期刊Biological Trace Element Research
182
發行號1
DOIs
出版狀態已發佈 - 一月 1 2018

指紋

Trace Elements
Pleural Effusion
Lung Neoplasms
L-Lactate Dehydrogenase
Glucose 1-Dehydrogenase
Glucose
Smoking
Metalloids
Proteins
Poisons
Metals
Observation
Tissue
Fluids
Neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

引用此文

@article{43d6283f02b34ef3bb1a77a4e7bf735f,
title = "Trace Elements in Pleural Effusion Correlates with Smokers with Lung Cancer",
abstract = "Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal. Analysis results revealed that among the biochemical parameters, only the glucose concentration was significantly higher in current smokers than in non-smokers; the other parameters showed no significant difference. The concentration of Zn in the PE was significantly lower in all smokers (10 former and 12 current smokers) than in non-smokers, but the other elements did not differ significantly between the two groups and smoker subgroups. Simultaneously, Zn correlated negatively with glucose concentrations in all smokers, positively with lactate dehydrogenase (LDH) concentration in current smoker, and positively with total protein (TP) concentrations in non-smokers. This is for the first time the relation between Zn and certain biochemical parameters in PE was found, the observation requiring further studies to explain the potential interactions between this element and glucose, LDH, and TP concentrations.",
keywords = "Biochemical parameter, Lung cancer, Pleural effusion, Smoker, Trace element",
author = "Lee, {Kang Yun} and Feng, {Po Hao} and Chuang, {Hsiao Chi} and Wu, {Sheng Ming} and Liu, {Wen Te} and Chen, {Kuan Yuan} and Liu, {Chien Ying} and Ho, {Shu Chuan}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s12011-017-1079-y",
language = "English",
volume = "182",
pages = "14--20",
journal = "Biological Trace Element Research",
issn = "0163-4984",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - Trace Elements in Pleural Effusion Correlates with Smokers with Lung Cancer

AU - Lee, Kang Yun

AU - Feng, Po Hao

AU - Chuang, Hsiao Chi

AU - Wu, Sheng Ming

AU - Liu, Wen Te

AU - Chen, Kuan Yuan

AU - Liu, Chien Ying

AU - Ho, Shu Chuan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal. Analysis results revealed that among the biochemical parameters, only the glucose concentration was significantly higher in current smokers than in non-smokers; the other parameters showed no significant difference. The concentration of Zn in the PE was significantly lower in all smokers (10 former and 12 current smokers) than in non-smokers, but the other elements did not differ significantly between the two groups and smoker subgroups. Simultaneously, Zn correlated negatively with glucose concentrations in all smokers, positively with lactate dehydrogenase (LDH) concentration in current smoker, and positively with total protein (TP) concentrations in non-smokers. This is for the first time the relation between Zn and certain biochemical parameters in PE was found, the observation requiring further studies to explain the potential interactions between this element and glucose, LDH, and TP concentrations.

AB - Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal. Analysis results revealed that among the biochemical parameters, only the glucose concentration was significantly higher in current smokers than in non-smokers; the other parameters showed no significant difference. The concentration of Zn in the PE was significantly lower in all smokers (10 former and 12 current smokers) than in non-smokers, but the other elements did not differ significantly between the two groups and smoker subgroups. Simultaneously, Zn correlated negatively with glucose concentrations in all smokers, positively with lactate dehydrogenase (LDH) concentration in current smoker, and positively with total protein (TP) concentrations in non-smokers. This is for the first time the relation between Zn and certain biochemical parameters in PE was found, the observation requiring further studies to explain the potential interactions between this element and glucose, LDH, and TP concentrations.

KW - Biochemical parameter

KW - Lung cancer

KW - Pleural effusion

KW - Smoker

KW - Trace element

UR - http://www.scopus.com/inward/record.url?scp=85021123261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021123261&partnerID=8YFLogxK

U2 - 10.1007/s12011-017-1079-y

DO - 10.1007/s12011-017-1079-y

M3 - Article

AN - SCOPUS:85021123261

VL - 182

SP - 14

EP - 20

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

IS - 1

ER -