Toxoplasma gondii infection: Seroprevalence and associated risk factors among primary schoolchildren in Lagos City, Southern Nigeria

Vincent Pam Gyang, Olaoluwa Pheabian Akinwale, Yueh Lun Lee, Ting Wu Chuang, Akwaowo Orok, Olusola Ajibaye, Chien Wei Liao, Po Ching Cheng, Chia Mei Chou, Ying Chieh Huang, Kuo Hua Fan, Chia Kwung Fan

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Introduction: Toxoplasma gondii infection has been described as the most widespread zoonotic infection of humans and other animals. Information concerning T. gondii infection among schoolchildren is unavailable in Lagos City, Nigeria. Methods: This crosssectional study investigated the seroprevalence and risk factors associated with T. gondii infection among primary schoolchildren (PSC) from a community located in the center of Lagos, southern Nigeria, from November 2013 to March 2014. A total of 382 PSC were screened for the presence of sera anti-T. gondii antibodies using a latex agglutination test (TOXO Test-MT, Tokyo, Japan). A cutofftiter of ≥ 1:32 was considered positive, while titers ≥ 1:1,024 indicated high responders. Questionnaires were also used to obtain data on possible risk factors from parents/guardians. Results: The overall seroprevalence was 24% (91/382), and 83.5% (76/91) of seropositive PSC were classified as high responders. Among the risk factors tested, including contact with cats and soil, consumption of raw meat and vegetables, and drinking unboiled water, none showed statistical significance after multivariate adjustment. No associations were observed among age, gender, body mass index (BMI), and parents’ occupation/educational level. Conclusions: The findings in this study show evidence of active infection, and hence, there is need for urgent preventive measures in this city. Further investigation is required to clarify the transmission routes. Policy makers also need to initiate prevention and control programs to protect pregnant women and immunocompromised patients in particular because they are more severely affected by T. gondii infection.
原文英語
頁(從 - 到)56-63
頁數8
期刊Revista da Sociedade Brasileira de Medicina Tropical
48
發行號1
DOIs
出版狀態已發佈 - 2015

指紋

Toxoplasmosis
Seroepidemiologic Studies
Nigeria
Parents
Latex Fixation Tests
Social Adjustment
Tokyo
Zoonoses
Immunocompromised Host
Administrative Personnel
Occupations
Drinking Water
Vegetables
Meat
Pregnant Women
Japan
Cats
Body Mass Index
Soil
Antibodies

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Parasitology
  • Medicine(all)

引用此文

Toxoplasma gondii infection : Seroprevalence and associated risk factors among primary schoolchildren in Lagos City, Southern Nigeria. / Gyang, Vincent Pam; Akinwale, Olaoluwa Pheabian; Lee, Yueh Lun; Chuang, Ting Wu; Orok, Akwaowo; Ajibaye, Olusola; Liao, Chien Wei; Cheng, Po Ching; Chou, Chia Mei; Huang, Ying Chieh; Fan, Kuo Hua; Fan, Chia Kwung.

於: Revista da Sociedade Brasileira de Medicina Tropical, 卷 48, 編號 1, 2015, p. 56-63.

研究成果: 雜誌貢獻文章

Gyang, Vincent Pam ; Akinwale, Olaoluwa Pheabian ; Lee, Yueh Lun ; Chuang, Ting Wu ; Orok, Akwaowo ; Ajibaye, Olusola ; Liao, Chien Wei ; Cheng, Po Ching ; Chou, Chia Mei ; Huang, Ying Chieh ; Fan, Kuo Hua ; Fan, Chia Kwung. / Toxoplasma gondii infection : Seroprevalence and associated risk factors among primary schoolchildren in Lagos City, Southern Nigeria. 於: Revista da Sociedade Brasileira de Medicina Tropical. 2015 ; 卷 48, 編號 1. 頁 56-63.
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abstract = "Introduction: Toxoplasma gondii infection has been described as the most widespread zoonotic infection of humans and other animals. Information concerning T. gondii infection among schoolchildren is unavailable in Lagos City, Nigeria. Methods: This crosssectional study investigated the seroprevalence and risk factors associated with T. gondii infection among primary schoolchildren (PSC) from a community located in the center of Lagos, southern Nigeria, from November 2013 to March 2014. A total of 382 PSC were screened for the presence of sera anti-T. gondii antibodies using a latex agglutination test (TOXO Test-MT, Tokyo, Japan). A cutofftiter of ≥ 1:32 was considered positive, while titers ≥ 1:1,024 indicated high responders. Questionnaires were also used to obtain data on possible risk factors from parents/guardians. Results: The overall seroprevalence was 24{\%} (91/382), and 83.5{\%} (76/91) of seropositive PSC were classified as high responders. Among the risk factors tested, including contact with cats and soil, consumption of raw meat and vegetables, and drinking unboiled water, none showed statistical significance after multivariate adjustment. No associations were observed among age, gender, body mass index (BMI), and parents’ occupation/educational level. Conclusions: The findings in this study show evidence of active infection, and hence, there is need for urgent preventive measures in this city. Further investigation is required to clarify the transmission routes. Policy makers also need to initiate prevention and control programs to protect pregnant women and immunocompromised patients in particular because they are more severely affected by T. gondii infection.",
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AU - Gyang, Vincent Pam

AU - Akinwale, Olaoluwa Pheabian

AU - Lee, Yueh Lun

AU - Chuang, Ting Wu

AU - Orok, Akwaowo

AU - Ajibaye, Olusola

AU - Liao, Chien Wei

AU - Cheng, Po Ching

AU - Chou, Chia Mei

AU - Huang, Ying Chieh

AU - Fan, Kuo Hua

AU - Fan, Chia Kwung

PY - 2015

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N2 - Introduction: Toxoplasma gondii infection has been described as the most widespread zoonotic infection of humans and other animals. Information concerning T. gondii infection among schoolchildren is unavailable in Lagos City, Nigeria. Methods: This crosssectional study investigated the seroprevalence and risk factors associated with T. gondii infection among primary schoolchildren (PSC) from a community located in the center of Lagos, southern Nigeria, from November 2013 to March 2014. A total of 382 PSC were screened for the presence of sera anti-T. gondii antibodies using a latex agglutination test (TOXO Test-MT, Tokyo, Japan). A cutofftiter of ≥ 1:32 was considered positive, while titers ≥ 1:1,024 indicated high responders. Questionnaires were also used to obtain data on possible risk factors from parents/guardians. Results: The overall seroprevalence was 24% (91/382), and 83.5% (76/91) of seropositive PSC were classified as high responders. Among the risk factors tested, including contact with cats and soil, consumption of raw meat and vegetables, and drinking unboiled water, none showed statistical significance after multivariate adjustment. No associations were observed among age, gender, body mass index (BMI), and parents’ occupation/educational level. Conclusions: The findings in this study show evidence of active infection, and hence, there is need for urgent preventive measures in this city. Further investigation is required to clarify the transmission routes. Policy makers also need to initiate prevention and control programs to protect pregnant women and immunocompromised patients in particular because they are more severely affected by T. gondii infection.

AB - Introduction: Toxoplasma gondii infection has been described as the most widespread zoonotic infection of humans and other animals. Information concerning T. gondii infection among schoolchildren is unavailable in Lagos City, Nigeria. Methods: This crosssectional study investigated the seroprevalence and risk factors associated with T. gondii infection among primary schoolchildren (PSC) from a community located in the center of Lagos, southern Nigeria, from November 2013 to March 2014. A total of 382 PSC were screened for the presence of sera anti-T. gondii antibodies using a latex agglutination test (TOXO Test-MT, Tokyo, Japan). A cutofftiter of ≥ 1:32 was considered positive, while titers ≥ 1:1,024 indicated high responders. Questionnaires were also used to obtain data on possible risk factors from parents/guardians. Results: The overall seroprevalence was 24% (91/382), and 83.5% (76/91) of seropositive PSC were classified as high responders. Among the risk factors tested, including contact with cats and soil, consumption of raw meat and vegetables, and drinking unboiled water, none showed statistical significance after multivariate adjustment. No associations were observed among age, gender, body mass index (BMI), and parents’ occupation/educational level. Conclusions: The findings in this study show evidence of active infection, and hence, there is need for urgent preventive measures in this city. Further investigation is required to clarify the transmission routes. Policy makers also need to initiate prevention and control programs to protect pregnant women and immunocompromised patients in particular because they are more severely affected by T. gondii infection.

KW - Latex agglutination test

KW - Nigeria

KW - Primary schoolchildren

KW - Risk factors

KW - Toxoplasma gondii

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