Toxicity assessments of Chalcone and some Synthetic Chalcone Analogues in a Zebrafish model

Ya Ting Lee, Tsorng Harn Fong, Hui Min Chen, Chao Yuan Chang, Yun Hsin Wang, Ching Yuh Chern, Yau Hung Chen

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a-d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.

原文英語
頁(從 - 到)641-650
頁數10
期刊Molecules
19
發行號1
DOIs
出版狀態已發佈 - 一月 2014

ASJC Scopus subject areas

  • 有機化學
  • 醫藥 (全部)

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