摘要
A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.
原文 | 英語 |
---|---|
頁(從 - 到) | 915-918 |
頁數 | 4 |
期刊 | Tetrahedron Letters |
卷 | 41 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 2月 5 2000 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 有機化學
- 藥物發現