Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Jing Ping Liou, Chen Y. Cheng

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)

摘要

A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

原文英語
頁(從 - 到)915-918
頁數4
期刊Tetrahedron Letters
41
發行號6
DOIs
出版狀態已發佈 - 二月 5 2000
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 有機化學
  • 藥物發現

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