Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Jing Ping Liou; Chen Y. Cheng

doi:10.1016/S0040-4039(99)02188-7

Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Jing Ping Liou, Chen Y. Cheng

研究成果: 雜誌貢獻 › 文章 › 同行評審

34 引文斯高帕斯（Scopus）

摘要

A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

原文	英語
頁（從 - 到）	915-918
頁數	4
期刊	Tetrahedron Letters
卷	41
發行號	6
DOIs	https://doi.org/10.1016/S0040-4039(99)02188-7
出版狀態	已發佈 - 2月 5 2000
對外發佈	是

ASJC Scopus subject areas

生物化學
有機化學
藥物發現

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10.1016/S0040-4039(99)02188-7

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AB - A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

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KW - Analgesics

KW - Palladium

KW - Palladium compounds

KW - Rearrangements

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Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

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