Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Jing Ping Liou; Chen Y. Cheng

doi:10.1016/S0040-4039(99)02188-7

Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Jing Ping Liou, Chen Y. Cheng

研究成果: 雜誌貢獻 › 文章 › 同行評審

31 引文斯高帕斯（Scopus）

摘要

A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

原文	英語
頁（從 - 到）	915-918
頁數	4
期刊	Tetrahedron Letters
卷	41
發行號	6
DOIs	https://doi.org/10.1016/S0040-4039(99)02188-7
出版狀態	已發佈 - 二月 5 2000
對外發佈	是

ASJC Scopus subject areas

生物化學
有機化學
藥物發現

存取文件

10.1016/S0040-4039(99)02188-7

其它文件與鏈接

Link to publication in Scopus

引用此

@article{5ba65a773a39453ebcbd92f260f29c26,

title = "Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton",

abstract = "A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.",

keywords = "Alkaloids, Analgesics, Palladium, Palladium compounds, Rearrangements",

author = "Liou, {Jing Ping} and Cheng, {Chen Y.}",

year = "2000",

month = feb,

day = "5",

doi = "10.1016/S0040-4039(99)02188-7",

language = "English",

volume = "41",

pages = "915--918",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Total synthesis of (±)-desoxycodeine-D

T2 - A novel route to the morphine skeleton

AU - Liou, Jing Ping

AU - Cheng, Chen Y.

PY - 2000/2/5

Y1 - 2000/2/5

N2 - A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

AB - A novel approach towards the construction of the morphine skeleton was demonstrated by a total synthesis of (±)-desoxycodeine-D (11) from 5,6,7,8- tetrahydroisoquinoline and isovanillin. The key steps are two consecutive Pd- catalyzed cyclizations and a Stevens rearrangement for the formation of ring B. (C) 2000 Elsevier Science Ltd.

KW - Alkaloids

KW - Analgesics

KW - Palladium

KW - Palladium compounds

KW - Rearrangements

UR - http://www.scopus.com/inward/record.url?scp=0034606984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034606984&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(99)02188-7

DO - 10.1016/S0040-4039(99)02188-7

M3 - Article

AN - SCOPUS:0034606984

VL - 41

SP - 915

EP - 918

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 6

ER -

Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

引用此