摘要

A total synthesis of denbinobin (1) in seven steps with an overall yield of 10% is reported. This synthesis used an FeCl3-assisted cyclization of stilbene to form a phenanthrene. The poor yields of the decarboxylation and methoxylation steps were improved upon to become essentially quantitative. This scalable methodology was carried out using ordinary laboratory reagents.

原文英語
頁(從 - 到)1170-1173
頁數4
期刊Journal of Natural Products
79
發行號4
DOIs
出版狀態已發佈 - 四月 22 2016

ASJC Scopus subject areas

  • 藥物發現
  • 藥理
  • 藥學科學
  • 分析化學
  • 有機化學
  • 分子醫學
  • 補充和替代醫學

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