摘要

A total synthesis of denbinobin (1) in seven steps with an overall yield of 10% is reported. This synthesis used an FeCl3-assisted cyclization of stilbene to form a phenanthrene. The poor yields of the decarboxylation and methoxylation steps were improved upon to become essentially quantitative. This scalable methodology was carried out using ordinary laboratory reagents.

原文英語
頁(從 - 到)1170-1173
頁數4
期刊Journal of Natural Products
79
發行號4
DOIs
出版狀態已發佈 - 四月 22 2016

指紋

Stilbenes
Decarboxylation
Cyclization
phenanthrene
denbinobin

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

引用此文

Total Synthesis of Denbinobin. / Lee, Hsueh Yun; Kumar, Sunil; Lin, Tzu Cheng; Liou, Jing Ping.

於: Journal of Natural Products, 卷 79, 編號 4, 22.04.2016, p. 1170-1173.

研究成果: 雜誌貢獻文章

Lee, Hsueh Yun ; Kumar, Sunil ; Lin, Tzu Cheng ; Liou, Jing Ping. / Total Synthesis of Denbinobin. 於: Journal of Natural Products. 2016 ; 卷 79, 編號 4. 頁 1170-1173.
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