Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Liang Chieh Chen, Kai Cheng Hsu, Lih Chu Chiou, Hui Ju Tseng, Wei Jan Huang

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To solve these problems, this study developed a novel scheme for synthesizing hispidulin, which had an improved overall yield as well as more concise reaction steps compared to previous methods reported. Additionally, using the same synthetic strategy, d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver microsome. This work may produce new chemical entities for enriching the library of hispidulin-derived compounds.
原文英語
文章編號1897
期刊Molecules
22
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2017

ASJC Scopus subject areas

  • Organic Chemistry

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