Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin, Chia Wen Ho, Leroy-Fong Liu, Yi Lisa Lyu

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

原文英語
頁(從 - 到)7182-7192
頁數11
期刊Journal of Biological Chemistry
288
發行號10
DOIs
出版狀態已發佈 - 三月 8 2013
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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