Titin: Major myofibrillar components of striated muscle

K. Wang, J. McClure, A. Tu

研究成果: 雜誌貢獻文章同行評審

425 引文 斯高帕斯(Scopus)

摘要

Electrophoretic analyses of protein components of striated muscle myofibril purified from various vertebrate and invertebrate species revealed that proteins much larger than myosin heavy chain are present in significant amounts. To define possible roles of these heretofore unidentified proteins, we purified a combination of two uncommonly large proteins, designated as titin, from chicken breast myofibrils. Chemical and immunological studies indicated that titin is distinct from myosin, actin and filamin. Specific titin antibody crossreacts with similar protein in both skeletal and cardiac myofibrils of many vertebrate and invertebrate species. Immunofluorescent staining of glycerinated chicken breast myofibrils indicated that titin is present in M lines, Z lines, the junctions of A and I bands, and perhaps throughout the entire A bands. Similar staining studies of myofibrils from other species suggest that titin-like proteins may be organized in all myofibrils according to a common architectural plan. We conclude that titin is a structurally conserved myofibrillar component of vertebrate and invertebrate striated muscles.

原文英語
頁(從 - 到)3698-3702
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
76
發行號8
DOIs
出版狀態已發佈 - 1979
對外發佈Yes

ASJC Scopus subject areas

  • General

指紋 深入研究「Titin: Major myofibrillar components of striated muscle」主題。共同形成了獨特的指紋。

引用此