Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: Association with clinicopathological parameters

Chi Ying Wu, Wei Hwa Lee, Jia Yi Wang, Hung Chiang, Junn Liang Chang, Wen Chiuan Tsai, Lai Fa Sheu, Jong Shiaw Jin

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

Accumulated evidence reveals that increased cyclooxygenase-2 (COX-2) is involved in the development of colorectal cancer. Our purpose was to quantitate COX-2 expression in colorectal cancers using tissue microarray analysis and look for an association with clinicopathological stage. Immunohistochemical analysis of COX-2 was performed in tissue microarray slides containing 90 specimens including 32 well-differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas. All colorectal adenocarcinomas showed significant immunohistochemical expression of COX-2 when compared to normal colon epithelia. However, there was no significant difference in immunostaining scores between poorly, moderately, and well-differentiated tumors (195 ± 28, 214 ± 26 and 200 ± 24, respectively). The COX-2 immunostaining score correlated significantly with T stage (P <0.05) but not with N or M stage. The positive expression rates of CK20 were 97% for welldifferentiated, 94% for moderately differentiated, and 65% for poorly differentiated colorectal adenocarcinomas, suggesting that CK20 may not be an effective discriminator between poorly differentiated colorectal adenocarcinoma and metastatic adenocarcinoma.

原文英語
頁(從 - 到)298-304
頁數7
期刊Chinese Journal of Physiology
49
發行號6
出版狀態已發佈 - 2006
對外發佈Yes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

指紋 深入研究「Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: Association with clinicopathological parameters」主題。共同形成了獨特的指紋。

  • 引用此