Tissue microarray analysis of interleukin-20 expression

Chung-Hsi Hsing, Chung Liang Ho, Lih Yun Chang, Yi Lin Lee, Shih Sung Chuang, Ming Shi Chang

研究成果: 雜誌貢獻文章

29 引文 (Scopus)

摘要

Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.

原文英語
頁(從 - 到)44-52
頁數9
期刊Cytokine
35
發行號1-2
DOIs
出版狀態已發佈 - 七月 2006
對外發佈Yes

指紋

Tissue Array Analysis
Microarrays
Tissue
Cells
interleukin 20
Macrophages
Endothelial cells
Tongue
Interleukin-10
Muscle Cells
Esophagus
Muscle
Tumors
Squamous Cell Carcinoma
Skin
Skeletal Muscle
Endothelial Cells
Epithelial Cells
Monoclonal Antibodies
Cytokines

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

引用此文

Hsing, C-H., Ho, C. L., Chang, L. Y., Lee, Y. L., Chuang, S. S., & Chang, M. S. (2006). Tissue microarray analysis of interleukin-20 expression. Cytokine, 35(1-2), 44-52. https://doi.org/10.1016/j.cyto.2006.07.006

Tissue microarray analysis of interleukin-20 expression. / Hsing, Chung-Hsi; Ho, Chung Liang; Chang, Lih Yun; Lee, Yi Lin; Chuang, Shih Sung; Chang, Ming Shi.

於: Cytokine, 卷 35, 編號 1-2, 07.2006, p. 44-52.

研究成果: 雜誌貢獻文章

Hsing, C-H, Ho, CL, Chang, LY, Lee, YL, Chuang, SS & Chang, MS 2006, 'Tissue microarray analysis of interleukin-20 expression', Cytokine, 卷 35, 編號 1-2, 頁 44-52. https://doi.org/10.1016/j.cyto.2006.07.006
Hsing C-H, Ho CL, Chang LY, Lee YL, Chuang SS, Chang MS. Tissue microarray analysis of interleukin-20 expression. Cytokine. 2006 7月;35(1-2):44-52. https://doi.org/10.1016/j.cyto.2006.07.006
Hsing, Chung-Hsi ; Ho, Chung Liang ; Chang, Lih Yun ; Lee, Yi Lin ; Chuang, Shih Sung ; Chang, Ming Shi. / Tissue microarray analysis of interleukin-20 expression. 於: Cytokine. 2006 ; 卷 35, 編號 1-2. 頁 44-52.
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