摘要
Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.
原文 | 英語 |
---|---|
頁(從 - 到) | 44-52 |
頁數 | 9 |
期刊 | Cytokine |
卷 | 35 |
發行號 | 1-2 |
DOIs | |
出版狀態 | 已發佈 - 7月 2006 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 免疫學和過敏
- 免疫學
- 生物化學
- 血液學
- 分子生物學