摘要
Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 44-52 |
| 頁數 | 9 |
| 期刊 | Cytokine |
| 卷 | 35 |
| 發行號 | 1-2 |
| DOIs | |
| 出版狀態 | 已發佈 - 七月 2006 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Immunology
- Immunology and Allergy
引用此文
Tissue microarray analysis of interleukin-20 expression. / Hsing, Chung-Hsi; Ho, Chung Liang; Chang, Lih Yun; Lee, Yi Lin; Chuang, Shih Sung; Chang, Ming Shi.
於: Cytokine, 卷 35, 編號 1-2, 07.2006, p. 44-52.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Tissue microarray analysis of interleukin-20 expression
AU - Hsing, Chung-Hsi
AU - Ho, Chung Liang
AU - Chang, Lih Yun
AU - Lee, Yi Lin
AU - Chuang, Shih Sung
AU - Chang, Ming Shi
PY - 2006/7
Y1 - 2006/7
N2 - Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.
AB - Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.
KW - Cytokines
KW - Interleukin-20
KW - Tissue microarray
UR - http://www.scopus.com/inward/record.url?scp=33749256771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749256771&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2006.07.006
DO - 10.1016/j.cyto.2006.07.006
M3 - Article
C2 - 16908179
AN - SCOPUS:33749256771
VL - 35
SP - 44
EP - 52
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 1-2
ER -