Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu; Yih Ming Wang; Long Sheng Lu; Chia Wei Sun; Chih Wei Lu; Meng Tsan Tsai; C. C. Yang

doi:10.1117/1.2812647

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu, Yih Ming Wang, Long Sheng Lu, Chia Wei Sun, Chih Wei Lu, Meng Tsan Tsai, C. C. Yang

研究成果: 雜誌貢獻 › 文章 › 同行評審

7 引文斯高帕斯（Scopus）

摘要

We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10^-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

原文	英語
文章編號	064022
期刊	Journal of Biomedical Optics
卷	12
發行號	6
DOIs	https://doi.org/10.1117/1.2812647
出版狀態	已發佈 - 11月 2007
對外發佈	是

ASJC Scopus subject areas

生物醫學工程
生物材料
電子、光磁材料
原子與分子物理與光學
放射學、核子醫學和影像學
放射與超音波技術
臨床生物化學

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abstract = "We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.",

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AU - Lu, Chih Wei

AU - Tsai, Meng Tsan

AU - Yang, C. C.

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Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

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