Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu, Yih Ming Wang, Long Sheng Lu, Chia Wei Sun, Chih Wei Lu, Meng Tsan Tsai, C. C. Yang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

原文英語
文章編號064022
期刊Journal of Biomedical Optics
12
發行號6
DOIs
出版狀態已發佈 - 11月 2007
對外發佈

ASJC Scopus subject areas

  • 生物醫學工程
  • 生物材料
  • 電子、光磁材料
  • 原子與分子物理與光學
  • 放射學、核子醫學和影像學
  • 放射與超音波技術
  • 臨床生物化學

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