Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses

Elena Candelotti, Paolo De Vito, Ragab G. Ahmed, Paolo Luly, Paul J. Davis, Jens Z. Pedersen, Hung Yun Lin, Sandra Incerpi

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Nongenomic effects of thyroid hormones typically start at the cell surface and do not primarily involve the classical nuclear receptors, but rather a plasma membrane receptor site identified about ten years ago on the integrin αvβ3. Transduction of the thyroid hormone signal from this integrin receptor involves activation of the MAPK pathway and may lead to events such as angiogenesis or tumor cell proliferation. This review focuses on the interaction of thyroid hormones with growth factors, in fact the integrin αvβ3 has been reported to a be a co-receptor for several growth factors such as EGF, IGF-1 and the FGF family, but also for small molecules like resveratrol. Binding of the ligand to integrin αvβ3 is inhibited by tetrac, a metabolite of L-thyroxine, and by its nanoparticulate formulation nanotetrac. Recent microarray studies on tumor cells have shown that tetrac has antiinflammatory effects that are mediated by integrin αvβ3, and tetrac can downregulate the expression of several interleukin genes. Crosstalk between thyroid hormones and vascular growth factors is important for cell migration, vascular calcification and the angiogenic process. Thyroid hormones also show pleiotropic effects on osteoblast function and differentiation, as well as in early pregnancy. The importance of thyroid hormone interaction with neurotrophins and interleukins has also been examined. With integrin αvβ3 firmly established as the plasma membrane receptor future studies will focus on the crosstalk between thyroid hormones and growth factors in order to verify the efficiency of new pharmacological tools, such as nanotetrac.
原文英語
頁(從 - 到)71-85
頁數15
期刊Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
15
發行號1
出版狀態已發佈 - 七月 1 2015

指紋

Thyroid Hormones
Intercellular Signaling Peptides and Proteins
Integrins
Interleukins
Cell Membrane
Vascular Calcification
Growth Factor Receptors
Nerve Growth Factors
Cytoplasmic and Nuclear Receptors
Osteoblasts
Insulin-Like Growth Factor I
Thyroxine
Epidermal Growth Factor
Cell Movement
Neoplasms
Anti-Inflammatory Agents
Down-Regulation
Cell Proliferation
Pharmacology
Ligands

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

引用此文

Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., ... Incerpi, S. (2015). Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 15(1), 71-85.

Thyroid hormones crosstalk with growth factors : Old facts and new hypotheses. / Candelotti, Elena; Vito, Paolo De; Ahmed, Ragab G.; Luly, Paolo; Davis, Paul J.; Pedersen, Jens Z.; Lin, Hung Yun; Incerpi, Sandra.

於: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 卷 15, 編號 1, 01.07.2015, p. 71-85.

研究成果: 雜誌貢獻文章

Candelotti, E, Vito, PD, Ahmed, RG, Luly, P, Davis, PJ, Pedersen, JZ, Lin, HY & Incerpi, S 2015, 'Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 卷 15, 編號 1, 頁 71-85.
Candelotti E, Vito PD, Ahmed RG, Luly P, Davis PJ, Pedersen JZ 等. Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2015 7月 1;15(1):71-85.
Candelotti, Elena ; Vito, Paolo De ; Ahmed, Ragab G. ; Luly, Paolo ; Davis, Paul J. ; Pedersen, Jens Z. ; Lin, Hung Yun ; Incerpi, Sandra. / Thyroid hormones crosstalk with growth factors : Old facts and new hypotheses. 於: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2015 ; 卷 15, 編號 1. 頁 71-85.
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