Thyroid hormone actions in liver cancer

Sheng Ming Wu, Wan Li Cheng, Crystal D. Lin, Kwang Huei Lin

研究成果: 雜誌貢獻回顧型文獻同行評審

17 引文 斯高帕斯(Scopus)

摘要

The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) mediates several physiological processes, including embryonic development, cellular differentiation, metabolism, and the regulation of cell proliferation. Thyroid hormone receptors (TRs) generally act as heterodimers with the retinoid X receptor (RXR) to regulate target genes. In addition to their developmental and metabolic functions, TRs have been shown to play a tumor suppressor role, suggesting that their aberrant expression can lead to tumor transformation. Conversely, recent reports have shown an association between overexpression of wild-type TRs and tumor metastasis. Signaling crosstalk between T3/TR and other pathways or specific TR coregulators appear to affect tumor development. Since TR actions are complex as well as cell context-, tissue- and time-specific, aberrant expression of the various TR isoforms has different effects during diverse tumorigenesis. Therefore, elucidation of the T 3/TR signaling mechanisms in cancers should facilitate the identification of novel therapeutic targets. This review provides a summary of recent studies focusing on the role of TRs in hepatocellular carcinomas (HCCs).
原文英語
頁(從 - 到)1915-1936
頁數22
期刊Cellular and Molecular Life Sciences
70
發行號11
DOIs
出版狀態已發佈 - 六月 2013
對外發佈

ASJC Scopus subject areas

  • 細胞生物學
  • 分子生物學
  • 分子醫學
  • 藥理
  • 細胞與分子神經科學

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