Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition

Ehab Abdelfadil, Ya Hsin Cheng, Da Tian Bau, Wei Jen Ting, Li Mien Chen, Hsi Hsien Hsu, Yueh Min Lin, Ray Jade Chen, Fu Jenn Tsai, Chang Hai Tsai, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

46 引文 斯高帕斯(Scopus)

摘要

Oral cancer is a common malignancy associated with high morbidity and mortality. While p38 MAPK is reported to be involved in different cellular activities such as proliferation and differentiation, reports rarely define the roles of the individual members of the p38 MAPK family in cancer. We used two unique cell lines developed by our lab representing chemically induced oral cancer cells (T28) and non-tumor cells (N28) obtained from tissues surrounding the induced cancer as a model to screen out whether p38 MAPK is involved in the malignant transformation processes. The results suggest an association between p38β not p38α and oral cancer development. Additionally, the anti-cancer activity of thymoquinone (TQ) was screened out and we found evidences suggesting that the anti-tumor activity of TQ may be attributed to the downregulation of p38β MAPK.

原文英語
頁(從 - 到)683-696
頁數14
期刊American Journal of Chinese Medicine
41
發行號3
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • 補充和替代醫學

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