Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients

Ming Jui Hung, Ning I. Yang, I. Wen Wu, Chi Wen Cheng, Ping Chang Liu, Shih Jen Chen, Mai Szu Wu, Wen Jin Cherng

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Background: The aim of this study was to investigate the relations of left ventricular (LV) mass and geometry to LV function in patients with predialysis chronic kidney disease (CKD), by real-time 3-dimensional echocardiography (RT3-DE). Methods: Echocardiography was performed on 76 consecutively enrolled patients (51 men) with different stages of CKD, including 26 patients with mild CKD (CKD stages 1-2) and 50 patients with moderate-tosevere CKD (CKD stages 3-5). LV mass and LV enddiastolic volume were measured by RT3-DE. Results: Greater prevalence of LV diastolic dysfunction and higher mitral E/myocardial velocities in early diastole (Em) values were noted in patients with moderate-to-severe CKD. In the moderate-tosevere CKD group, patients with increased LV mass had lower myocardial velocities in peak systole (Sm) and longer isovolumic relaxation time (IVRT). In the mild CKD group, patients with increased LV mass to volume ratios had lower Em. Moderate-to-severe CKD was associated with lower Sm and Em and higher mitral rapid filling to Em (E/Em) ratios by LV mass quartile stratification. Using LV mass/volume quartile stratification, moderate-to-severe CKD was associated with longer IVRT, lower Sm and higher mitral E/Em. Multivariable logistic regression analysis showed that CKD severity was the most independent predictor of elevated LV filling pressure (odds ratio = 2.96, p=0.019). Conclusions: Increased LV mass impaired LV contraction and relaxation in patients with moderate-to-severe CKD. Concentric remodeling impaired LV diastolic function in patients with mild CKD. CKD severity was positively associated with elevated LV filling pressure.

原文英語
頁(從 - 到)96-106
頁數11
期刊Journal of Nephrology
25
發行號1
DOIs
出版狀態已發佈 - 二月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Nephrology

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