Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone

Ruoxiang Wang, Jianchun Xu, Lisa Juliette, Agapito Castilleja, John Love, Shian Ying Sung, Haiyen E. Zhau, Thomas J. Goodwin, Leland W K Chung

研究成果: 雜誌貢獻文章同行評審

72 引文 斯高帕斯(Scopus)

摘要

Cancer-stromal interaction results in the co-evolution of both the cancer cells and the surrounding host stromal cells. As a consequence of this interaction, cancer cells acquire increased malignant potential and stromal cells become more inductive. In this review we suggest that cancer-stromal interaction can best be investigated by three-dimensional (3D) co-culture models with the results validated by clinical specimens. We showed that 3D culture promoted bone formation in vitro, and explored for the first time, with the help of the astronauts of the Space Shuttle Columbia, the co-culture of human prostate cancer and bone cells to further understand the interactions between these cells. Continued exploration of cancer growth under 3D conditions will rapidly lead to new discoveries and ultimately to improvements in the treatment of men with hormonal refractory prostate cancer.
原文英語
頁(從 - 到)353-364
頁數12
期刊Seminars in Cancer Biology
15
發行號5 SPEC. ISS.
DOIs
出版狀態已發佈 - 十月 2005
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research

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