Third and second harmonic generation imaging of human articular cartilage

Ming Rung Tsai; Chih-Hwa Chen; Chi Kuang Sun

doi:10.1117/12.809968

Third and second harmonic generation imaging of human articular cartilage

Ming Rung Tsai, Chih-Hwa Chen, Chi Kuang Sun

研究成果: 書貢獻/報告類型 › 會議貢獻

7 引文斯高帕斯（Scopus）

摘要

Cartilage matrix is damaged in diseased states such as osteoarthritis while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.

原文	英語
主出版物標題	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
卷	7183
DOIs	https://doi.org/10.1117/12.809968
出版狀態	已發佈 - 2009
對外發佈	Yes
事件	Multiphoton Microscopy in the Biomedical Sciences IX - San Jose, CA, 美国持續時間: 一月 25 2009 → 一月 27 2009

其他

其他	Multiphoton Microscopy in the Biomedical Sciences IX
國家	美国
城市	San Jose, CA
期間	1/25/09 → 1/27/09

ASJC Scopus subject areas

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1117/12.809968

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引用此

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abstract = "Cartilage matrix is damaged in diseased states such as osteoarthritis while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.",

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KW - Chondrocyte

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