Therapeutice effects of baicalin on lipopolysaccharide-induced acute lung injury in rats

Kun Lun Huang, Chien Sheng Chen, Ching Wang Hsu, Min Hui Li, Hung Chang, Shih Hung Tsai, Shi Jye Chu

研究成果: 雜誌貢獻文章

29 引文 斯高帕斯(Scopus)

摘要

Baicalin is a flavonoid present in many traditional Chinese medicines. A number of studies show that baicalin has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The effect of baicalin in lipopolysaccharide (LPS)-induced acute lung injury is not well studied. In this study, typically acute lung injury was induced in rat by intratracheal injection of LPS, which increased lactate dehydrogenase activity and protein content in bronchoalveolar lavage fluid, wet/dry lung weight ratio, Evan's blue dye leakage, and neutrophil infiltration. Baicalin (20 mg/kg) was administrated 1 hour before or 30 min after LPS injection. Both pre and post-treatment with baicalin attenuated the increase of these parameters and improved histological finding. Our results suggest that baicalin has a therapeutic effect on LPS-induced acute lung injury.

原文英語
頁(從 - 到)301-311
頁數11
期刊American Journal of Chinese Medicine
36
發行號2
DOIs
出版狀態已發佈 - 2008
對外發佈Yes

ASJC Scopus subject areas

  • Complementary and alternative medicine

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