Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases

研究成果: 雜誌貢獻回顧型文獻

摘要

Cardiovascular diseases (CVDs) are among the leading threats to human health. The advanced glycation end product (AGE) and receptor for AGE (RAGE) signaling pathway regulates the pathogenesis of CVDs, through its effects on arterial stiffness, atherosclerosis, mitochondrial dysfunction, oxidative stress, calcium homeostasis, and cytoskeletal function. Targeting the AGE/RAGE pathway is a potential therapeutic strategy for ameliorating CVDs. Vitamin D has several beneficial effects on the cardiovascular system. Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.
原文英語
期刊Cellular and Molecular Life Sciences
DOIs
出版狀態接受/付印 - 一月 1 2019

指紋

Vitamin D
Cardiovascular Diseases
Therapeutics
Vascular Stiffness
Advanced Glycosylation End Products
Cardiovascular System
Atherosclerosis
Oxidative Stress
Homeostasis
Advanced Glycosylation End Product-Specific Receptor
Calcium
Health

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

引用此文

@article{4186f81ef00d46b895d605f9305a8214,
title = "Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases",
abstract = "Cardiovascular diseases (CVDs) are among the leading threats to human health. The advanced glycation end product (AGE) and receptor for AGE (RAGE) signaling pathway regulates the pathogenesis of CVDs, through its effects on arterial stiffness, atherosclerosis, mitochondrial dysfunction, oxidative stress, calcium homeostasis, and cytoskeletal function. Targeting the AGE/RAGE pathway is a potential therapeutic strategy for ameliorating CVDs. Vitamin D has several beneficial effects on the cardiovascular system. Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.",
keywords = "Calcitriol, Diabetic cardiomyopathy, Inflammation, Ischemia–reperfusion injury, Myocarditis",
author = "Lee, {Ting Wei} and Kao, {Yu Hsun} and Chen, {Yi Jen} and Chao, {Tze Fan} and Lee, {Ting I.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00018-019-03204-3",
language = "English",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",

}

TY - JOUR

T1 - Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases

AU - Lee, Ting Wei

AU - Kao, Yu Hsun

AU - Chen, Yi Jen

AU - Chao, Tze Fan

AU - Lee, Ting I.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Cardiovascular diseases (CVDs) are among the leading threats to human health. The advanced glycation end product (AGE) and receptor for AGE (RAGE) signaling pathway regulates the pathogenesis of CVDs, through its effects on arterial stiffness, atherosclerosis, mitochondrial dysfunction, oxidative stress, calcium homeostasis, and cytoskeletal function. Targeting the AGE/RAGE pathway is a potential therapeutic strategy for ameliorating CVDs. Vitamin D has several beneficial effects on the cardiovascular system. Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.

AB - Cardiovascular diseases (CVDs) are among the leading threats to human health. The advanced glycation end product (AGE) and receptor for AGE (RAGE) signaling pathway regulates the pathogenesis of CVDs, through its effects on arterial stiffness, atherosclerosis, mitochondrial dysfunction, oxidative stress, calcium homeostasis, and cytoskeletal function. Targeting the AGE/RAGE pathway is a potential therapeutic strategy for ameliorating CVDs. Vitamin D has several beneficial effects on the cardiovascular system. Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.

KW - Calcitriol

KW - Diabetic cardiomyopathy

KW - Inflammation

KW - Ischemia–reperfusion injury

KW - Myocarditis

UR - http://www.scopus.com/inward/record.url?scp=85068147499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068147499&partnerID=8YFLogxK

U2 - 10.1007/s00018-019-03204-3

DO - 10.1007/s00018-019-03204-3

M3 - Review article

AN - SCOPUS:85068147499

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

ER -