Therapeutic potential of drugs targeting pathophysiology of intracerebral hemorrhage: From animal models to clinical applications

Kuo Hsing Liao, Chih Wei Sung, Ya Ni Huang, Wei Jiun Li, Po Chuan Yu, Jia Yi Wang

研究成果: 雜誌貢獻回顧型文獻同行評審

8 引文 斯高帕斯(Scopus)

摘要

Background: Intracerebral hemorrhage (ICH) is one of the most common forms of cerebral hemorrhage, the morbidity and death of ICH is high worldwide. ICH can be spontaneous or caused by hypertension, coagulopathy, angiopathy, head trauma, bleeding disorders, tumors, or drug usage. ICH is the most serious and least treatable form of hemorrhagic stroke, with rapidly increasing hematoma size and often resulting in significant brain injury and long term neurological deficits. Surgical hematoma evacuation remains controversial. The currently therapy is mainly supportive with limited benefit. New therapeutic approaches are desperately needed. Methods: In this review, we provide an overview of the published literature concerning the pathophysiology leading to the ongoing neurologic damage, Emerging information of the physio-pathologic mechanisms of injury that occur after ICH is available from current animal models. Ideal therapeutic strategies should target on the pathophysiology of ICH. This review summarizes the recent advances in developing pharmaceutical agents in terms of therapeutic targets and effects in pre-clinical and clinical studies. Results: Recent animal and clinical studies have provided important information about the parallel and sequential deleterious mechanisms underlying ICH-induced brain injury and pharmacological agents targeting on these mechanisms. Neuroscientists have paid more attention to novel drug development that target on antioxidants, antiinflammatory, and anti-apoptosis for neuroprotection after ICH. Conclusion: Although ICH remains without an approved treatment proven to decrease morbidity and mortality, notable advances in the understanding of ICH pathophysiology and new drug development have been made in the last decade.
原文英語
頁(從 - 到)2212-2225
頁數14
期刊Current Pharmaceutical Design
23
發行號15
DOIs
出版狀態已發佈 - 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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