Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas

Yu Tang Tung, Hsiao Ling Chen, Hsin Chung Tsai, Shang Hsun Yang, Yi Chun Chang, Chuan Mu Chen

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14 引文 斯高帕斯(Scopus)

摘要

Andrographolide is one of the major diterpene lactones found in Andrographis paniculata Nees and exhibits remarkable inhibitory effects on various cancers. In this study, the antipulmonary cancer effects of andrographolide were studied in a lung tumor mouse model induced by human vascular endothelial growth factor A165 (hVEGF-A165). These results demonstrated that andrographolide significantly reduced the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs. In addition, andrographolide also decreased tumor formation by reducing VEGF, EGFR, Cyclin A, and Cyclin B expression on the transcriptional and translational levels. These results indicated that andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice. In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future.
原文英語
文章編號305898
期刊Evidence-based Complementary and Alternative Medicine
2013
DOIs
出版狀態已發佈 - 2013
對外發佈Yes

ASJC Scopus subject areas

  • Complementary and alternative medicine

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