The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

I. Ching Chou, Fuu Jen Tsai, Chao Ching Huang, Cheng Chieh Lin, Chang Hai Tsai

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

原文英語
頁(從 - 到)1971-1973
頁數3
期刊NeuroReport
13
發行號15
出版狀態已發佈 - 十月 28 2002
對外發佈Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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