The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma

H. J. Harn, L. I. Ho, C. P. Yu, M. W. Wang, H. S. Lee, J. J. Lin, W. H. Lee, N. R. Isola, D. L. Cooper

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The interaction of the cell surface receptor CD44 molecular with its ligands (addressin, extracellular matrix etc.,) plays an important role in fulfilling the lymphocyte homing and immune reaction. Recently alternatively spliced products of CD44 gene are found to be involved in tumor metastasis as well. Our report found that CD44 prototype RNA (CD44S) was present in all five tumor cell lines. Isoform CD44 RNA (CD44V) was recognized in three metastasized hepatocellular carcinoma cell lines, J5, HCC36, HEP38. In addition, the J5 CD44 RNA isoform expressed two distinct trancripts which are of the same size as MDA-231 breast tumor cell line. The MDA-231 CD44 RNA variant (CD44V) has been confirmed to contain metastasis domain 4 and 5. it is implicated that the alternative RNA splicing may also play a major role in hepatocellular carcinoma metastasis.

原文英語
頁(從 - 到)233-238
頁數6
期刊Biochemistry and Molecular Biology International
32
發行號2
出版狀態已發佈 - 1994
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 遺傳學
  • 分子生物學

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