The value of pyrans as anticancer scaffolds in medicinal chemistry

Dinesh Kumar, Pooja Sharma, Harmanpreet Singh, Kunal Nepali, Girish Kumar Gupta, Subheet Kumar Jain, Fidele Ntie-Kang

研究成果: 雜誌貢獻回顧型文獻同行評審

106 引文 斯高帕斯(Scopus)


Pyran is an oxygen-containing heterocyclic moiety, which exhibits an array of pharmacological properties. Pyran is also one of the important structural subunits found widely in natural products, e.g. coumarins, benzopyrans, sugars, flavonoids, xanthones, etc. The diverse anticancer capabilities of pyrans have been additionally evidenced by the fact that this heterocycle has recently been a focal point for researchers worldwide. This review provides a summary of pyran-based anticancer compounds, with emphasis on the past 10 years. It focuses on advancements in the field of naturally occurring pyrans as anticancer agents. The discussion also includes structure-activity relationships, along with the structures of the most promising molecules, their biological activities against several human cancer cell lines, as well as mechanistic insights discovered through the pharmacological evaluation and molecular modeling of pyran-based molecules. The promising activities revealed by these pyran-based scaffolds undoubtedly place them at the forefront for the discovery of prospective drug candidates. Thus, they could therefore be of great interest to researchers working on the synthesis of antitumour drug candidates.
頁(從 - 到)36977-36999
期刊RSC Advances
出版狀態已發佈 - 1月 1 2017

ASJC Scopus subject areas

  • 化學 (全部)
  • 化學工程 (全部)


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