The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH

P. Harrison, J. Alsousou, I. Andia, T. Burnouf, D. Dohan Ehrenfest, P. Everts, H. Langer, J. Magalon, R. Marck, P. Gresele

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

摘要

Summary: Autologous and single-donor allogenic platelet preparations are increasingly being used in many areas of regenerative medicine. However, there are few properly controlled randomized clinical trials, and the preparation, content and characteristics of platelet preparations are generally poorly defined and controlled. The Platelet Physiology Subcommittee of the Scientific and Standardization Committee (SSC) of the ISTH formed a working party of experts with the aim of producing consensus recommendations for guidance on the use of platelets in regenerative medicine. Owing to a lack of investigations that provide definitive evidence for the efficacy, definition and use of different platelet preparations in regenerative medicine, there were insufficient data to develop evidence-based guidelines. Therefore, the RAND method was used, which obtains a formal consensus among experts particularly when scientific evidence is absent, scarce and/or heterogeneous. Using this approach, each expert scored as ‘appropriate’, ‘uncertain’ or ‘inappropriate’ a series of 45 statements about the practice of regenerative medicine with platelets, which included different sections on general aspects, platelet preparations, clinical trial design, and potential utility in different clinical scenarios. After presentation and public discussion at SSC meetings, the assessments were further refined to produce final consensus recommendations, which constitute the subject of the present report.
原文英語
頁(從 - 到)1895-1900
頁數6
期刊Journal of Thrombosis and Haemostasis
16
發行號9
DOIs
出版狀態已發佈 - 九月 1 2018
對外發佈Yes

ASJC Scopus subject areas

  • Hematology

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    Harrison, P., Alsousou, J., Andia, I., Burnouf, T., Dohan Ehrenfest, D., Everts, P., Langer, H., Magalon, J., Marck, R., & Gresele, P. (2018). The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 16(9), 1895-1900. https://doi.org/10.1111/jth.14223