The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal

Marcela Rosas, Luke C. Davies, Peter J. Giles, Chia Te Liao, Bashar Kharfan, Timothy C. Stone, Valerie B. O'Donnell, Donald J. Fraser, Simon A. Jones, Philip R. Taylor

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229 引文 斯高帕斯(Scopus)

摘要

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.

原文英語
頁(從 - 到)645-648
頁數4
期刊Science
344
發行號6184
DOIs
出版狀態已發佈 - 2014
對外發佈

ASJC Scopus subject areas

  • 多學科

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