The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

J. L. Crawford, F. J. Kolpak, A. H. Wang, G. J. Quigley, J. H. van Boom, G. van der Marel, A. Rich

研究成果: 雜誌貢獻文章同行評審

148 引文 斯高帕斯(Scopus)

摘要

The structure of the tetramer d(CpGpCpG) has been solved by x-ray analysis in two different crystal forms with and without spermine cations. The molecules crystallize in hexagonal unit cells and they form a left-handed double helix of Z-DNA similar to that previously reported for the hexamer d(CpGpCpGpCpG). In the crystal lattice the molecules stack together to form a virtually continuous left-handed double helix in which every fourth phosphate group is missing. The stacking of bases upon each other is similar to that seen in the hexamer. However, the base pairs have a slightly different orientation in that the cytosine residues are slightly removed from the axis of the molecule compared to the position they occupy in the hexamer. The structures are similar in two crystal forms with and without spermine cations.

原文英語
頁(從 - 到)4016-4020
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
77
發行號7
DOIs
出版狀態已發佈 - 7月 1980
對外發佈

ASJC Scopus subject areas

  • 多學科

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