The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho, Hao Ching Wang, Tzu Ping Ko, Yuan Chih Chang, Andrew H J Wang

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.

Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.

Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.

Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.
原文英語
頁(從 - 到)27046-27054
頁數9
期刊Journal of Biological Chemistry
289
發行號39
DOIs
出版狀態已發佈 - 九月 26 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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