The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang, C. C. Chen, S. Y. Lee, L. H. Shen, H. E. Wang

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3 引文 斯高帕斯(Scopus)

摘要

6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.
原文英語
頁(從 - 到)1397-1400
頁數4
期刊Applied Radiation and Isotopes
67
發行號7-8
DOIs
出版狀態已發佈 - 七月 1 2009

ASJC Scopus subject areas

  • 輻射

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