The suppression of peritoneal cellular immunity in women with endometriosis could be restored after gonadotropin releasing hormone agonist treatment

Ming Yih Wu, Kuang Han Chao, Shee Uan Chen, Hsin F.U. Chen, Y. U.Shih Yang, S. U.Cheng Huang, Hong Nerng Ho

研究成果: 雜誌貢獻文章同行評審

41 引文 斯高帕斯(Scopus)

摘要

Problem: Our previous study reported that peritoneal natural killer (NK) cytotoxicity and CD3 + CD25 + lymphocyte subpopulation were suppressed in women with advanced endometriosis. Whether these phenomena are general for all stages of endometriosis and whether these alterations could be restored by long-term use of gonadotropin releasing hormone agonist (GnRHa) are further tested in this study. Method: Lymphocyte subpopulations (B cells, NK cells, T cells, and T-cell activation markers such as CD69, HLA-DR, and CD25) and NK cell cytotoxicity of peripheral blood and peritoneal fluid by dual-color flow cytometry and 51 Cr release assay in 30 cases of endometriosis were compared with those in 26 controls. We also compared these changes before and after 6-month treatment with GnRHa for advanced endometriosis. Results: Compared with the controls, only those women with advanced endometriosis showed lower NK cytotoxicity in peritoneal fluid mononuclear cells (PFMC). The CD3 + CD69 + lymphocyte subpopulation decreased in peripheral blood mononuclear cells (PBMC) of advanced endometriosis, while the CD3 + CD25+ lymphocyte subpopulation decreased in both PBMC and PFMC of mild and advanced endometriosis. After GnRHa treatment, the CD3 + CD69 + lymphocyte subpopulation increased in both PBMC and PFMC and the CD3 + CD25 + lymphocyte subpopulation increased in PFMC, but not in PBMC. Conclusion: Impaired local immunological function in the PF of endometriosis was confirmed by this study and the impairments could be restored after long-term GnRHa therapy.
原文英語
頁(從 - 到)510-516
頁數7
期刊American Journal of Reproductive Immunology
35
發行號6
DOIs
出版狀態已發佈 - 1月 1 1996
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 生殖醫學
  • 婦產科

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