The structural study of copper-binding peptides: Implication in the aggregation of amyloid-β peptides

Ren Jie Lin, Tzyy Rong Jinn, Soonmin Jang, Fur Der Mai, Feng Yin Li

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

There is evidence that copper is bound to amyloid-β peptide (Aβ) in senile plaque of Alzheimer's disease. Copper also plays a role in the neurotoxicity of the Aβ aggregates associated with free radical damage. In this study, we used L-histidyl-L-histidine peptide (di-histidine) to represent Aβ along with ab initio calculation to characterize the probable coordination between Cu(II) and Aβs to explore the Aβ aggregate structures. Sixteen models of copper-di-histidine complexes were proposed to investigate the copper-induced aggregation of Aβs through copper ionic coordination. All structures of the proposed models were optimized at the M05-2X/LanL2DZ level, and an Aβ aggregation formation mechanism was proposed.

原文英語
頁(從 - 到)891-897
頁數7
期刊Journal of the Chinese Chemical Society
60
發行號7
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • Chemistry(all)

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