The stability of prostaglandin E1 ethylester

Lun Huei Lin, Hsiu O. Ho, Kuo Tung Chen, Han-Sun Chiang, Patrick Y K Wong, Ming Thau Sheu

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to identify the conversion pathways of prostaglandin E1 (PGE1) ethylester during the stability tests in phosphate buffers (pH 7.4) and saline system at various temperature. A reversed phase HPLC system with a photodiode array detector was used to differentiate the UV spectrum of degradation species. By the comparison of UV spectrum of each chromatographic peak, it was confirmed that the dominate degradation pathway of PGE1 ethylester in phosphate buffer, as well as in 0.9 % NaCl solution, was the sequential formation of PGA1 ethylester and then PGB1 ethylester. A first-order reaction model could be used to describe the degradation of PGE1 ethylester via this route. The activation energy calculated by Arrhenius equation was 19.83 (2.11) and 21.67 (3.33) kcal/mole, respectively, for the reaction in these two media.
原文英語
頁(從 - 到)97-105
頁數9
期刊Chinese Pharmaceutical Journal
50
發行號2
出版狀態已發佈 - 四月 1998

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

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  • 引用此

    Lin, L. H., Ho, H. O., Chen, K. T., Chiang, H-S., Wong, P. Y. K., & Sheu, M. T. (1998). The stability of prostaglandin E1 ethylester. Chinese Pharmaceutical Journal, 50(2), 97-105.