The significance of human papillomavirus viral load in prediction of histologic severity and size of squamous intraepithelial lesions of uterine cervix

Chien An Sun, Hung Cheng Lai, Cheng Chang Chang, Sin Neih, Cheng Ping Yu, Tang Yuan Chu

研究成果: 雜誌貢獻文章

94 引文 斯高帕斯(Scopus)

摘要

Objectives. Persistence of high-risk types of human papillomavirus (HPV) in cervical scrapes is responsible for the development, maintenance, and progression of squamous intraepithelial lesions (SILs). Previous studies of viral load and histologic severity have ended with controversial results. This study evaluated the relationships of HPV viral load with size and histologic severity of cervical lesions, which has not been reported previously. Methods. By using Hybrid Capture II, DNA level of high-risk HPVs was determined in cervical scrapes and correlated with lesion size and histologic confirmation for 73 women referred for colposcopy. The lesion size was classified as nonvisible (n=12), small (≤2/5 of the 12× colposcopic visual filed, n=36), and large (>2/5 of the 12× field, n=25) lesions. The final disease status was categorized as high-grade SIL (HSIL)/squamous cell carcinoma (SCC) (designated HSIL+) (n=32), low-grade SIL (LSIL) (n=19), and no detectable SIL (n=22). Results. A distinct upward trend of high-risk HPV DNA levels paralleled increasing size and histologic severity of cervical lesions (P=0.003 and 0.001, respectively). With respect to relative risk, women who had high viral load of HPV were at significantly greater risk for large lesion size (odds ratio [OR]=5.3, 95% confidence interval [CI]=1.1-24.9) and HSIL+ (OR=35.0, 95% CI=4.2-294.5). Of particular note, the risk of developing large lesion size and HSIL+ significantly increased with increasing viral load of HPV (P values for trend test were 0.008 and 0.0004, respectively). In contrast, there were no significant associations of trend in viral load with risk in small lesion size and LSIL. Conclusions. The present study revealed that the effect of HPV infection on SIL development is highly influenced by high viral load and highlighted a potential application of viral load testing in predicting the size and severity of lesions of the uterine cervix.

原文英語
頁(從 - 到)95-99
頁數5
期刊Gynecologic Oncology
83
發行號1
DOIs
出版狀態已發佈 - 2001
對外發佈Yes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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