The safety and efficacy of alfentanil-based induction in bronchoscopy sedation: A randomized, double-blind, controlled trial

Chung Hsing Hsieh, Ting Yu Lin, Tsai Yu Wang, Chih Hsi Kuo, Shu Min Lin, Han Pin Kuo, Yu Lun Lo

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: Alfentanil in combination with propofol produces a synergistic sedative effect in patients undergoing flexible bronchoscopy (FB). However, the use of this combination is controversial due to the risk of cardiopulmonary depression. The aim of this study was to evaluate the proper induction regimen of alfentanil in propofol target-controlled infusion for FB sedation. Methods:One hundred seventy-three patients were assigned randomly into 5 regimens: Group 1 and 2, alfentanil 2.5 and 5mg/kg, respectively, immediately before propofol administration; Group 3 and 4, alfentanil 2.5 and 5mg/kg, respectively, 2minutes before propofol administration; and Group 5, propofol administration alone to achieve the observer assessment of alertness and sedation scale 3∼2. The bronchoscopists, physicians in charge of sedation, and patients were blind to the regimens. Adverse events, drug dose, induction, procedure and recovery time, cough severity, and propofol injection related pain were recorded. Results: The patients in groups 2 and 4 required a lower dose of propofol (P=0.031 and 0.019, respectively) and shorter time (P=0.035 and 0.010) than group 5 for induction. Patients in group 2 experienced more hypoxemia than those in group 5 during induction (P=0.031). The physician in charge of sedation scored a lower severity of cough in the patients in group 4 than in groups 3 and 5. There were no differences in terms of propofol injection related pain among the groups. Conclusion: Alfentanil 5mg/kg given immediately before propofol infusion cannot be recommended. Further study is required to define conclusions about alfentanil 2.5 and 5mg/kg because of the low power rating of subgroup in the present study.
原文英語
文章編號e5101
期刊Medicine (United States)
95
發行號43
DOIs
出版狀態已發佈 - 1月 1 2016
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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