摘要

This chapter discusses the role of mitochondria in aging ovary. Human mitochondrial deoxyribonucleic acid (mtDNA) is a maternally inherited double-stranded circular DNA molecule, which is involved in respiratory and oxidative phosphorylation. The human metaphase II oocyte is estimated to have 100,000 mitochondria; however, there is only one mitochondrial genome per organelle. The mtDNA is not protected by histones and is exposed in high concentrations of reactive oxygen species (ROS) and free radicals in the matrix of mitochondria. Thus, the aged oocytes are very vulnerable to oxidative damage and mtDNA mutation. The current study demonstrates that mtDNA 4977bp deletions in compromised human oocytes may range from 56.3% when maternal age is younger than 32 up to 73% when maternal age is older than 37. Most nondisjunction and aneuplodies take place during meiosis, which are highly energy-intensive, and increase exponentially with maternal age. Mitochondria in oocyte and early embryos are structurally immature. They are round or ovoid, with few cristae. They become more elongated with numerous transverse cristae at the blastocyst stage. Nevertheless, after ovulation the multiplication of mitochondria and the replication of mtDNA are not resumed until the gastrulation stage.

原文英語
主出版物標題The Ovary: Second Edition
發行者Elsevier Inc.
頁面569-575
頁數7
ISBN(列印)9780080542584, 9780124445628
DOIs
出版狀態已發佈 - 十二月 18 2003

指紋

Ovary
Mitochondria
Oocytes
DNA
Maternal Age
Reactive Oxygen Species
Circular DNA
Gastrulation
Mitochondrial Genome
Oxidative Phosphorylation
Meiosis
Blastocyst
Metaphase
Ovulation
Organelles
Histones
Free Radicals
Embryonic Structures
Mutation

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Hsieh, R. H., Au, H. K., Wang, R. S., Yang, P. S., & Tzeng, C. R. (2003). The Role of Mitochondria in the Aging Ovary. 於 The Ovary: Second Edition (頁 569-575). Elsevier Inc.. https://doi.org/10.1016/B978-012444562-8/50035-5

The Role of Mitochondria in the Aging Ovary. / Hsieh, Rong Hong; Au, Heng Kien; Wang, Ruey Sheng; Yang, Peng Sheng; Tzeng, Chii Ruey.

The Ovary: Second Edition. Elsevier Inc., 2003. p. 569-575.

研究成果: 書貢獻/報告類型章節

Hsieh, RH, Au, HK, Wang, RS, Yang, PS & Tzeng, CR 2003, The Role of Mitochondria in the Aging Ovary. 於 The Ovary: Second Edition. Elsevier Inc., 頁 569-575. https://doi.org/10.1016/B978-012444562-8/50035-5
Hsieh RH, Au HK, Wang RS, Yang PS, Tzeng CR. The Role of Mitochondria in the Aging Ovary. 於 The Ovary: Second Edition. Elsevier Inc. 2003. p. 569-575 https://doi.org/10.1016/B978-012444562-8/50035-5
Hsieh, Rong Hong ; Au, Heng Kien ; Wang, Ruey Sheng ; Yang, Peng Sheng ; Tzeng, Chii Ruey. / The Role of Mitochondria in the Aging Ovary. The Ovary: Second Edition. Elsevier Inc., 2003. 頁 569-575
@inbook{3fd9954de6dd4b5498349833dc643e7f,
title = "The Role of Mitochondria in the Aging Ovary",
abstract = "This chapter discusses the role of mitochondria in aging ovary. Human mitochondrial deoxyribonucleic acid (mtDNA) is a maternally inherited double-stranded circular DNA molecule, which is involved in respiratory and oxidative phosphorylation. The human metaphase II oocyte is estimated to have 100,000 mitochondria; however, there is only one mitochondrial genome per organelle. The mtDNA is not protected by histones and is exposed in high concentrations of reactive oxygen species (ROS) and free radicals in the matrix of mitochondria. Thus, the aged oocytes are very vulnerable to oxidative damage and mtDNA mutation. The current study demonstrates that mtDNA 4977bp deletions in compromised human oocytes may range from 56.3{\%} when maternal age is younger than 32 up to 73{\%} when maternal age is older than 37. Most nondisjunction and aneuplodies take place during meiosis, which are highly energy-intensive, and increase exponentially with maternal age. Mitochondria in oocyte and early embryos are structurally immature. They are round or ovoid, with few cristae. They become more elongated with numerous transverse cristae at the blastocyst stage. Nevertheless, after ovulation the multiplication of mitochondria and the replication of mtDNA are not resumed until the gastrulation stage.",
author = "Hsieh, {Rong Hong} and Au, {Heng Kien} and Wang, {Ruey Sheng} and Yang, {Peng Sheng} and Tzeng, {Chii Ruey}",
year = "2003",
month = "12",
day = "18",
doi = "10.1016/B978-012444562-8/50035-5",
language = "English",
isbn = "9780080542584",
pages = "569--575",
booktitle = "The Ovary: Second Edition",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - The Role of Mitochondria in the Aging Ovary

AU - Hsieh, Rong Hong

AU - Au, Heng Kien

AU - Wang, Ruey Sheng

AU - Yang, Peng Sheng

AU - Tzeng, Chii Ruey

PY - 2003/12/18

Y1 - 2003/12/18

N2 - This chapter discusses the role of mitochondria in aging ovary. Human mitochondrial deoxyribonucleic acid (mtDNA) is a maternally inherited double-stranded circular DNA molecule, which is involved in respiratory and oxidative phosphorylation. The human metaphase II oocyte is estimated to have 100,000 mitochondria; however, there is only one mitochondrial genome per organelle. The mtDNA is not protected by histones and is exposed in high concentrations of reactive oxygen species (ROS) and free radicals in the matrix of mitochondria. Thus, the aged oocytes are very vulnerable to oxidative damage and mtDNA mutation. The current study demonstrates that mtDNA 4977bp deletions in compromised human oocytes may range from 56.3% when maternal age is younger than 32 up to 73% when maternal age is older than 37. Most nondisjunction and aneuplodies take place during meiosis, which are highly energy-intensive, and increase exponentially with maternal age. Mitochondria in oocyte and early embryos are structurally immature. They are round or ovoid, with few cristae. They become more elongated with numerous transverse cristae at the blastocyst stage. Nevertheless, after ovulation the multiplication of mitochondria and the replication of mtDNA are not resumed until the gastrulation stage.

AB - This chapter discusses the role of mitochondria in aging ovary. Human mitochondrial deoxyribonucleic acid (mtDNA) is a maternally inherited double-stranded circular DNA molecule, which is involved in respiratory and oxidative phosphorylation. The human metaphase II oocyte is estimated to have 100,000 mitochondria; however, there is only one mitochondrial genome per organelle. The mtDNA is not protected by histones and is exposed in high concentrations of reactive oxygen species (ROS) and free radicals in the matrix of mitochondria. Thus, the aged oocytes are very vulnerable to oxidative damage and mtDNA mutation. The current study demonstrates that mtDNA 4977bp deletions in compromised human oocytes may range from 56.3% when maternal age is younger than 32 up to 73% when maternal age is older than 37. Most nondisjunction and aneuplodies take place during meiosis, which are highly energy-intensive, and increase exponentially with maternal age. Mitochondria in oocyte and early embryos are structurally immature. They are round or ovoid, with few cristae. They become more elongated with numerous transverse cristae at the blastocyst stage. Nevertheless, after ovulation the multiplication of mitochondria and the replication of mtDNA are not resumed until the gastrulation stage.

UR - http://www.scopus.com/inward/record.url?scp=84942758405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942758405&partnerID=8YFLogxK

U2 - 10.1016/B978-012444562-8/50035-5

DO - 10.1016/B978-012444562-8/50035-5

M3 - Chapter

AN - SCOPUS:84942758405

SN - 9780080542584

SN - 9780124445628

SP - 569

EP - 575

BT - The Ovary: Second Edition

PB - Elsevier Inc.

ER -