The role of microparticles in inflammation and transfusion: A concise review

Fabrice Cognasse, Hind Hamzeh-Cognasse, Sandrine Laradi, Ming Li Chou, Jerard Seghatchian, Thierry Burnouf, Chantal Boulanger, Olivier Garraud, Nicolas Amabile

研究成果: 雜誌貢獻回顧型文獻

48 引文 斯高帕斯(Scopus)

摘要

Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.
原文英語
頁(從 - 到)159-167
頁數9
期刊Transfusion and Apheresis Science
53
發行號2
DOIs
出版狀態已發佈 - 十月 1 2015

ASJC Scopus subject areas

  • Hematology

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    Cognasse, F., Hamzeh-Cognasse, H., Laradi, S., Chou, M. L., Seghatchian, J., Burnouf, T., Boulanger, C., Garraud, O., & Amabile, N. (2015). The role of microparticles in inflammation and transfusion: A concise review. Transfusion and Apheresis Science, 53(2), 159-167. https://doi.org/10.1016/j.transci.2015.10.013