The role of igf/igf-1r signaling in hepatocellular carcinomas: Stemness-related properties and drug resistance

Mai Huong Thi Ngo, Han Yin Jeng, Yung Che Kuo, Josephine Diony Nanda, Ageng Brahmadhi, Thai Yen Ling, Te Sheng Chang, Yen Hua Huang

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem cell pluripotency and differentiation to trigger cell proliferation, organ development, and tissue regeneration during embryonic development. Unbalanced IGF/IGF-1R signaling can promote cancer cell proliferation and activate cancer reprogramming in tumor tissues, especially in the liver. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, with a high incidence and mortality rate in Asia. Most patients with advanced HCC develop tyrosine kinase inhibitor (TKI)-refractoriness after receiving TKI treatment. Dysregulation of IGF/IGF-1R signaling in HCC may activate expression of cancer stemness that leads to TKI refractoriness and tumor recurrence. In this review, we summarize the evidence for dysregulated IGF/IGF-1R signaling especially in hepatitis B virus (HBV)-associated HCC. The regulation of cancer stemness expression and drug resistance will be highlighted. Current clinical treatments and potential therapies targeting IGF/IGF-1R signaling for the treatment of HCC will be discussed.

原文英語
文章編號1931
頁(從 - 到)1-34
頁數34
期刊International journal of molecular sciences
22
發行號4
DOIs
出版狀態已發佈 - 二月 2 2021

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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