The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease

Chong H. Sam, Hsein K. Lu

研究成果: 雜誌貢獻回顧型文獻

22 引文 (Scopus)

摘要

Hypochlorous acid (HOCl) has both proinflammatory and anti-inflammatory properties, and seems to play an important role in the immune system. The regulation of normal flora contributes to periodontal health, and HOCI seems to have the ability to attack Gram-negative pathogens during periodontitis. Furthermore, high concentrations of HOCl promote healing by regulating cytokines and growth factors, killing pathogens through chlorination or oxidation, and modulating inflammation through the effects on nuclear factor κB and activator protein-1 of monocytes. After chlo-rination of taurine by HOCl, taurine chloramine is mostly an anti-inflammatory agent and enhances healing. Neither HOCl nor taurine chloramine are common in clinical applications owing to a lack of studies in animal and human models. Both compounds may be suitable as periodontal medication, as they are good antimicrobial agents, inflammation modulators, and healing promoters.
原文英語
頁(從 - 到)45-54
頁數10
期刊Journal of Dental Sciences
4
發行號2
DOIs
出版狀態已發佈 - 六月 2009

指紋

Hypochlorous Acid
Periodontal Diseases
Reactive Oxygen Species
Anti-Inflammatory Agents
Inflammation
Periodontitis
Halogenation
Taurine
Transcription Factor AP-1
Anti-Infective Agents
Monocytes
Immune System
Intercellular Signaling Peptides and Proteins
Animal Models
Cytokines
Health
N-chlorotaurine

ASJC Scopus subject areas

  • Dentistry(all)

引用此文

The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. / Sam, Chong H.; Lu, Hsein K.

於: Journal of Dental Sciences, 卷 4, 編號 2, 06.2009, p. 45-54.

研究成果: 雜誌貢獻回顧型文獻

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